1-(But-3-yn-1-yl)piperidine → 4-[5-(4-Piperidin-1-yl-but-1-ynyl)-pyridin-3-ylmethyl]-morpholine

Participants

Role	Name	HCID	Charge
Reactant	1-(But-3-yn-1-yl)piperidine	HCID 13155986	—
Reactant	4-((5-Bromopyridin-3-yl)methyl)morpholine	HCID 22390415	—
Product	4-[5-(4-Piperidin-1-yl-but-1-ynyl)-pyridin-3-ylmethyl]-morpholine	HCID 11609341	—

Reaction Steps

This compound was made in a similar way as described in Example 18, Step D, using 4-(5-bromo-pyridin-3-ylmethyl)-morpholine and 1-but-3-ynyl-piperidine (57%). MS (ESI): exact mass calcd. for C19H27N3O, 313.45; m/z found, 314.5 [M+H]+. 1H NMR (500 MHz, CDCl3): 8.49 (d, J=1.9,1H), 8.40 (d, J=1.6,1H), 7.66-7.64 (m, 1H), 3.68 (t, J=4.5, 4H), 3.45 (s, 2H), 2.67-2.58 (m, 4H), 2.49-2.38 (m, 8H), 1.62-1.52 (m, 4H), 1.46-1.40 (m, 2H).

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US07423147B2
Source dataset	uspto-grants-2008_09
ORD ID	ord-25c488fc0aa04321abbd095fd4f6b735
Source note	uspto-grants-2008_09