Dichlorodimethylsilane → 7-Mercapto-3,4-dihydro-2H-isoquinolin-1-one

HRID 304753Notes

Reaction equation

HRID 304753 reaction equation
[CH3:21][N:22]1[CH2:23][CH2:24][N:25]([CH3:26])[C:27]1=[O:28].[Cl:1][Si:2]([Cl:3])([CH3:4])[CH3:5].[O:6]=[C:7]1[NH:8][CH2:9][CH2:10][c:11]2[cH:12][cH:13][c:14]([S:17]([Cl:18])(=[O:19])=[O:20])[cH:15][c:16]21.[Zn:29]>>[O:6]=[C:7]1[NH:8][CH2:9][CH2:10][c:11]2[cH:12][cH:13][c:14]([SH:17])[cH:15][c:16]21

Participants

5

Reactant 4

HCID 6398DichlorodimethylsilaneHCID 66611,3-Dimethyl-2-imidazolidinoneHCID 23994ZincHCID 180713741-Oxo-1,2,3,4-tetrahydroisoquinoline-7-sulfonyl chloride

Product 1

HCID 642254267-Mercapto-3,4-dihydro-2H-isoquinolin-1-one

Sources & evidence

ORD record
ord-41687183b2544b3eacb819bfa34deb3a
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (8/10)

Reaction notes

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