HuagongsheHuagongshe Chemistry Print Report · For research reference only
N,N,N',N',N'',N''-Hexamethylmethanetriamine → (S)-5-diethylcarbamoyl-4-((E)-2-dimethylamino-vinyl)-5-ethyl-2-oxo-2,5-dihydro-furan-3-carboxylic acid ethyl ester
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | N,N,N',N',N'',N''-Hexamethylmethanetriamine | HCID 79831 | — |
| Reactant | 2-oxo-butyric acid (1R,2S,5R)-5-methyl-2-(1-methyl-1-phenyl-ethyl)-cyclohexyl ester | HCID 11088396 | — |
| Reactant | (S)-5-diethylcarbamoyl-5-ethyl-4-methyl-2-oxo-2,5-dihydro-furan-3-carboxylic acid ethyl ester | HCID 11687992 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | (S)-5-diethylcarbamoyl-4-((E)-2-dimethylamino-vinyl)-5-ethyl-2-oxo-2,5-dihydro-furan-3-carboxylic acid ethyl ester | HCID 11523197 | — |
Reaction Steps
According to the procedure described in Example 6 1.22 0 g of compound (23) as obtained from example 17 (4.103 mmol) in 7.3 mL dimethyl formamide were treated with 7.55 mL tris(dimethylamino)methane (42.26 mmol, 10.3 eq) yielding the crude product as an orange oil (1.463 mg, 101% by weight).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07423152B2 |
| Source dataset | uspto-grants-2008_09 |
| ORD ID | ord-bbd7d798654d40d2a16d1a5d7de0ddf3 |
| Source note | uspto-grants-2008_09 |