Potassium Carbonate → 3-Amino-2-(1-[3,4-dimethylphenylcarbonylmethyl]benzimidazol-2-yl)-1,2,4-triazole

Participants

Role	Name	HCID	Charge
Reactant	Potassium Carbonate	HCID 11430	—
Reactant	2-(1H-Benzoimidazol-2-YL)-2H-[1,2,4]triazol-3-ylamine	HCID 608264	—
Reactant	2-Bromo-1-(3,4-dimethylphenyl)ethan-1-one	HCID 3703113	—
Solvent	Water	HCID 962	—
Product	3-Amino-2-(1-[3,4-dimethylphenylcarbonylmethyl]benzimidazol-2-yl)-1,2,4-triazole	HCID 11233278	—

Reaction Steps

A suspension of 3-amino-2-(1H-benzimidazol-2-yl)-1,2,4-triazole (0.15 g, 0.75 mol), 3,4-dimethyl phenacyl bromide (0.204 g, 0.9 mmol) and dry potassium carbonate (0.258 g, 1.87 mmol) is stirred at room temperature for 16 hours. The mixture is diluted with water and the product extracted with ethyl acetate. The product is purified by chromatography on silicagel. M.p. 190-193° C., 1H-NMR (400 MHz, d6-DMSO): 7.84 (m, 1H); 7.77 (m, 3H); 7.65 (m, 2H); 7.50 (s, 1H); 7.33 (d, 1H); 6.22 (s, 2H); 2.30 (s, 6H).

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US07423157B2
Source dataset	uspto-grants-2008_09
ORD ID	ord-ecd8d20f50624f239d7c702deaa50531
Source note	uspto-grants-2008_09