HuagongsheHuagongshe Chemistry Print Report · For research reference only
Water → N-[2-(4-Fluorophenoxy)ethyl]-N'-(7-hydroxy-5,6,7,8-tetrahydronaphthalen-1-yl)urea
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Water | HCID 962 | — |
| Reactant | 2-(4-Fluorophenoxy)ethanamine | HCID 3135849 | — |
| Reactant | Phenyl (7-hydroxy-5,6,7,8-tetrahydronaphthalen-1-yl)carbamate | HCID 59731048 | — |
| Solvent | Dimethyl Sulfoxide | HCID 679 | — |
| Product | N-[2-(4-Fluorophenoxy)ethyl]-N'-(7-hydroxy-5,6,7,8-tetrahydronaphthalen-1-yl)urea | HCID 9798211 | 89.2% |
Reaction Steps
To 2-(4-Fluorophenoxy)ethylamine (27.4 mg, 0.18 mmol) was added a solution of (7-Hydroxy-5,6,7,8-tetrahydro-naphthalen-1-yl)-carbamic acid phenyl ester (50.0 mg, 0.18 mmol) in 1.5 mL dimethylsulfoxide. The mixture was stirred for 40 minutes, and then poured into water. The resulting solid was filtered and dried under reduced pressure (54.2 mg, 89.2% yield).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07423175B2 |
| Source dataset | uspto-grants-2008_09 |
| ORD ID | ord-a01ed4381c1e4a8b800c8cca04785229 |
| Source note | uspto-grants-2008_09 |