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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 30538Generated: October 25, 2026

Water → N-[2-(4-Fluorophenoxy)ethyl]-N'-(7-hydroxy-5,6,7,8-tetrahydronaphthalen-1-yl)urea

https://huagongshe.com/reaction/30538

Reaction equation

Participants

RoleNameHCIDCharge
ReactantWaterHCID 962—
Reactant2-(4-Fluorophenoxy)ethanamineHCID 3135849—
ReactantPhenyl (7-hydroxy-5,6,7,8-tetrahydronaphthalen-1-yl)carbamateHCID 59731048—
SolventDimethyl SulfoxideHCID 679—
ProductN-[2-(4-Fluorophenoxy)ethyl]-N'-(7-hydroxy-5,6,7,8-tetrahydronaphthalen-1-yl)ureaHCID 979821189.2%

Reaction Steps

To 2-(4-Fluorophenoxy)ethylamine (27.4 mg, 0.18 mmol) was added a solution of (7-Hydroxy-5,6,7,8-tetrahydro-naphthalen-1-yl)-carbamic acid phenyl ester (50.0 mg, 0.18 mmol) in 1.5 mL dimethylsulfoxide. The mixture was stirred for 40 minutes, and then poured into water. The resulting solid was filtered and dried under reduced pressure (54.2 mg, 89.2% yield).

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS07423175B2
Source datasetuspto-grants-2008_09
ORD IDord-a01ed4381c1e4a8b800c8cca04785229
Source noteuspto-grants-2008_09