Water → 3-(5,6-Dichloro-pyridin-3-yl)-3,6-diazabicyclo[3.2.0]-heptane

HRID 305383Notes

Reaction equation

HRID 305383 reaction equation
[CH3:22][O:23][CH2:24][CH2:25][O:26][CH3:27].[NH2:1][CH:2]1[CH:3]([CH2:15][OH:16])[CH2:4][N:5]([c:7]2[cH:8][n:9][c:10]([Cl:14])[c:11]([Cl:13])[cH:12]2)[CH2:6]1.[OH2:21].[S:17]([Cl:18])([Cl:19])=[O:20]>>[NH:1]1[CH:2]2[CH:3]([CH2:4][N:5]([c:7]3[cH:8][n:9][c:10]([Cl:14])[c:11]([Cl:13])[cH:12]3)[CH2:6]2)[CH2:15]1

Participants

5

Reactant 4

HCID 962WaterHCID 80711,2-DimethoxyethaneHCID 24386Thionyl ChlorideHCID 72359918[4-Amino-1-(5,6-dichloro-3-pyridinyl)pyrrolidin-3-yl]methanol

Product 1

HCID 226468863-(5,6-Dichloro-pyridin-3-yl)-3,6-diazabicyclo[3.2.0]-heptane

Sources & evidence

ORD record
ord-a26f48a29fa043a3a1e50069a70d844f
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (8/10)

Reaction notes

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