Dichloromethane → Benzyl 2-[[4-[4-(cyclopropylsulfonylamino)phenyl]-1,3-thiazol-2-yl]carbamoyl]pyrrolidine-1-carboxylate

HRID 306010Notes

Reaction equation

HRID 306010 reaction equation
[CH2:1]([c:2]1[cH:3][cH:4][cH:5][cH:6][cH:7]1)[O:8][C:9](=[O:10])[N:11]1[CH:12]([C:16]([NH:17][c:18]2[s:19][cH:20][c:21](-[c:23]3[cH:24][cH:25][c:26]([NH2:29])[cH:27][cH:28]3)[n:22]2)=[O:30])[CH2:13][CH2:14][CH2:15]1.[CH:31]1([S:34](=[O:35])(=[O:36])[Cl:37])[CH2:32][CH2:33]1.[Cl:38][CH2:39][Cl:40]>>[CH2:1]([c:2]1[cH:3][cH:4][cH:5][cH:6][cH:7]1)[O:8][C:9](=[O:10])[N:11]1[CH:12]([C:16]([NH:17][c:18]2[s:19][cH:20][c:21](-[c:23]3[cH:24][cH:25][c:26]([NH:29][S:34]([CH:31]4[CH2:32][CH2:33]4)(=[O:35])=[O:36])[cH:27][cH:28]3)[n:22]2)=[O:30])[CH2:13][CH2:14][CH2:15]1

Participants

4

Reactant 3

HCID 6344DichloromethaneHCID 2760919Cyclopropanesulfonyl chlorideHCID 57849733Benzyl 2-[[4-(4-aminophenyl)-1,3-thiazol-2-yl]carbamoyl]pyrrolidine-1-carboxylate

Product 1

HCID 74316251Benzyl 2-[[4-[4-(cyclopropylsulfonylamino)phenyl]-1,3-thiazol-2-yl]carbamoyl]pyrrolidine-1-carboxylate

Sources & evidence

ORD record
ord-fbaaf3bd33a64585b7d664b3d6cfe4c2
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (8/10)

Reaction notes

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