4-((3-Bromophenyl)sulphonyl)morpholine → 5-[2-Morpholin-4-yl-7-(3-morpholin-4-ylsulfonylphenyl)-5,6-dihydropyrrolo[2,3-d]pyrimidin-4-yl]pyrimidin-2-amine

HRID 306230Notes

Reaction equation

HRID 306230 reaction equation
[Br:41][c:42]1[cH:43][c:44]([S:45]([N:46]2[CH2:47][CH2:48][O:49][CH2:50][CH2:51]2)(=[O:52])=[O:53])[cH:54][cH:55][cH:56]1.[CH3:1][O:2][c:3]1[cH:4][cH:5][c:6]([CH2:7][N:8]([CH2:9][c:10]2[cH:11][cH:12][c:13]([O:14][CH3:15])[cH:16][cH:17]2)[c:18]2[n:19][cH:20][c:21](-[c:22]3[c:23]4[c:27]([n:28][c:29]([N:30]5[CH2:31][CH2:32][O:33][CH2:34][CH2:35]5)[n:36]3)[NH:26][CH2:25][CH2:24]4)[cH:37][n:38]2)[cH:39][cH:40]1.[CH3:57][O:58][c:59]1[cH:60][cH:61][c:62]([CH2:63][N:64]([c:65]2[n:66][cH:67][c:68](-[c:71]3[c:72]4[c:73]([n:74][c:75]([N:77]5[CH2:78][CH2:79][O:80][CH2:81][CH2:82]5)[n:76]3)[N:83]([c:86]3[cH:87][c:88]([S:92](=[O:93])(=[O:94])[N:95]5[CH2:96][CH2:97][O:98][CH2:99][CH2:100]5)[cH:89][cH:90][cH:91]3)[CH2:84][CH2:85]4)[cH:69][n:70]2)[CH2:101][c:102]2[cH:103][cH:104][c:105]([O:106][CH3:107])[cH:108][cH:109]2)[cH:110][cH:111]1>>[NH2:64][c:65]1[n:66][cH:67][c:68](-[c:71]2[c:72]3[c:73]([n:74][c:75]([N:77]4[CH2:78][CH2:79][O:80][CH2:81][CH2:82]4)[n:76]2)[N:83]([c:86]2[cH:87][c:88]([S:92](=[O:93])(=[O:94])[N:95]4[CH2:96][CH2:97][O:98][CH2:99][CH2:100]4)[cH:89][cH:90][cH:91]2)[CH2:84][CH2:85]3)[cH:69][n:70]1

Participants

4

Reactant 3

HCID 36960024-((3-Bromophenyl)sulphonyl)morpholineHCID 45258862Bis-(4-methoxybenzyl)-[5-(2-morpholin-4-yl-6,7-dihydro-5H-pyrrolo[2,3-d]pyrimidin-4-yl)-pyrimidin-2-yl]-amineHCID 67385447bis-(4-methoxy-benzyl)-(5-{7-[3-(morpholine-4-sulfonyl)-phenyl]-2-morpholin-4-yl-6,7-dihydro-5H-pyrrolo[2,3-d]pyrimidin-4-yl}-pyrimidin-2-yl)-amine

Product 1

HCID 592443075-[2-Morpholin-4-yl-7-(3-morpholin-4-ylsulfonylphenyl)-5,6-dihydropyrrolo[2,3-d]pyrimidin-4-yl]pyrimidin-2-amine

Sources & evidence

ORD record
ord-8e49e1c2ae1845169045739700c5e2a5
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (8/10)

Reaction notes

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