HuagongsheHuagongshe Chemistry Print Report · For research reference only
Tetrahydrofuran → 3-[5-(4-fluorophenyl)-1-methyl-1H-pyrazol-4-yl]propionic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Tetrahydrofuran | HCID 8028 | — |
| Reactant | (2E)-3-[5-(4-fluorophenyl)-1-methyl-1H-pyrazol-4-yl]acrylic acid | HCID 69208981 | — |
| Reactant | HCID 178418361 | HCID 178418361 | — |
| Catalyst | HCID 178418390 | HCID 178418390 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | 3-[5-(4-fluorophenyl)-1-methyl-1H-pyrazol-4-yl]propionic acid | HCID 69209928 | 97% |
Reaction Steps
A mixture of (2E)-3-[5-(4-fluorophenyl)-1-methyl-1H-pyrazol-4-yl]acrylic acid (0.80 g), 5% palladium-carbon (0.30 g), tetrahydrofuran (10 ml) and ethanol (10 ml) was stirred at room temperature for 6 hrs. in a hydrogen atmosphere at atmospheric pressure. Palladium-carbon was filtered off and the filtrate was concentrated to give 3-[5-(4-fluorophenyl)-1-methyl-1H-pyrazol-4-yl]propionic acid (0.78 g, yield 97%) as a colorless solid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07423159B2 |
| Source dataset | uspto-grants-2008_09 |
| ORD ID | ord-dd014909edac47f18110df883cab990e |
| Source note | uspto-grants-2008_09 |