Isoindoline → 4-[7-(1,3-Dihydro-2H-isoindol-2-ylcarbonyl)-3,4-dihydroisoquinolin-2(1H)-yl]-6-(4-methylpiperazin-1-yl)pyrimidin-2-amine

HRID 306751Notes

Reaction equation

HRID 306751 reaction equation
[CH2:28]1[NH:29][CH2:30][c:31]2[cH:32][cH:33][cH:34][cH:35][c:36]21.[NH2:1][c:2]1[n:3][c:4]([N:21]2[CH2:22][CH2:23][N:24]([CH3:27])[CH2:25][CH2:26]2)[cH:5][c:6]([N:8]2[CH2:9][c:10]3[cH:11][c:12]([C:18](=[O:19])[OH:20])[cH:13][cH:14][c:15]3[CH2:16][CH2:17]2)[n:7]1>>[NH2:1][c:2]1[n:3][c:4]([N:21]2[CH2:22][CH2:23][N:24]([CH3:27])[CH2:25][CH2:26]2)[cH:5][c:6]([N:8]2[CH2:9][c:10]3[cH:11][c:12]([C:18](=[O:19])[N:29]4[CH2:28][c:36]5[c:31]([cH:32][cH:33][cH:34][cH:35]5)[CH2:30]4)[cH:13][cH:14][c:15]3[CH2:16][CH2:17]2)[n:7]1

Participants

3

Reactant 2

HCID 422478IsoindolineHCID 594022702-[2-Amino-6-(4-methylpiperazin-1-yl)pyrimidin-4-yl]-1,2,3,4-tetrahydroisoquinoline-7-carboxylic acid

Product 1

HCID 594022654-[7-(1,3-Dihydro-2H-isoindol-2-ylcarbonyl)-3,4-dihydroisoquinolin-2(1H)-yl]-6-(4-methylpiperazin-1-yl)pyrimidin-2-amine

Sources & evidence

ORD record
ord-6e5ca196f60d4cce8fd8d39033332866
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (8/10)

Reaction notes

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