HuagongsheHuagongshe Chemistry Print Report · For research reference only
Dimethylformamide dimethyl acetal → 4-(Dimethylamino)-3-(4-fluorophenyl)but-3-en-2-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Dimethylformamide dimethyl acetal | HCID 78373 | — |
| Reactant | (4-Fluorophenyl)acetone | HCID 521187 | — |
| Solvent | Hexane | HCID 8058 | — |
| Product | 4-(Dimethylamino)-3-(4-fluorophenyl)but-3-en-2-one | HCID 68989809 | 83% |
Reaction Conditions
| Temperature | 120 °C |
|---|
Reaction Steps
A mixture of 1-(4-fluorophenyl)-2-propanone (10.0 g) and N,N-dimethylformamide dimethylacetal (8.00 g) was stirred at 120° C. for 2 hrs. The reaction mixture was cooled, and hexane was added to the precipitated solids, which were collected by filtration to give 4-(dimethylamino)-3-(4-fluorophenyl)but-3-en-2-one (11.3 g, yield 83%) as a pale-yellow solid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07423159B2 |
| Source dataset | uspto-grants-2008_09 |
| ORD ID | ord-483135ff7bc34f6c97c645a76cf27359 |
| Source note | uspto-grants-2008_09 |