7-Amino-6-fluoro-1,2,3,4-tetrahydroquinolin-2-one → 6-Fluoro-7-[7-(6-methoxy-pyridin-3-yl)-pyrrolo[2,1-f][1,2,4]triazin-2-ylamino]-3,4-dihydro-1H-quinolin-2-one

HRID 307556Notes

Reaction equation

HRID 307556 reaction equation
[CH3:1][O:2][c:3]1[cH:4][cH:5][c:6](-[c:9]2[cH:10][cH:11][c:12]3[cH:13][n:14][c:15]([O:18][S:19]([C:20]([F:21])([F:22])[F:23])(=[O:24])=[O:25])[n:16][n:17]23)[cH:7][n:8]1.[NH2:26][c:27]1[c:28]([F:38])[cH:29][c:30]2[c:35]([cH:36]1)[NH:34][C:33](=[O:37])[CH2:32][CH2:31]2>>[CH3:1][O:2][c:3]1[cH:4][cH:5][c:6](-[c:9]2[cH:10][cH:11][c:12]3[cH:13][n:14][c:15]([NH:26][c:27]4[c:28]([F:38])[cH:29][c:30]5[c:35]([cH:36]4)[NH:34][C:33](=[O:37])[CH2:32][CH2:31]5)[n:16][n:17]23)[cH:7][n:8]1

Participants

3

Reactant 2

HCID 120408227-Amino-6-fluoro-1,2,3,4-tetrahydroquinolin-2-oneHCID 86661684Trifluoro-methanesulfonic acid 7-(6-methoxy-pyridin-3-yl)-pyrrolo[2,1-f][1,2,4]triazin-2-yl ester

Product 1

HCID 667123996-Fluoro-7-[7-(6-methoxy-pyridin-3-yl)-pyrrolo[2,1-f][1,2,4]triazin-2-ylamino]-3,4-dihydro-1H-quinolin-2-one

Sources & evidence

ORD record
ord-98445149ffe9491aa03cf06b1ba5949a
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (8/10)

Reaction notes

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