反应详情

温度

80 °C

The same procedures set forth above in Example (1)(a) for synthesizing 3(3,4,5-trifluorophenyl)thiophene were followed, with the exception that 1-bromo-2,4-difluorobenzene was substituted for 1-bromo-3,4,5-trifluorobenzene as the 1-bromo-substituted fluorobenzene, and the coupling reaction mixture was heated to reflux in an oil bath for 10 hours with stirring at 80° C. (as opposed to being heated in an oil bath for 0.5 hour with periodically stirring). No further purification by recrystallization was required to obtain a 97 to 98% pure product.

1. customthe coupling reaction mixture
2. temperaturewas heated
3. temperatureto reflux in an oil bath for 10 hours
4. temperatureto being heated in an oil bath for 0.5 hour
5. stirringwith periodically stirring)
6. customNo further purification
7. customby recrystallization