Dichloromethane → 1,1-Dimethylethyl {2-[(8-(2,6-difluorophenyl)-4-{2-methyl-5-[(propylamino)carbonyl]phenyl}-7-oxo-7,8-dihydro-pyrido[2,3-d]pyrimidin-2-yl)amino]ethyl}methylcarbamate
Reaction equation
[Cl:49][CH2:50][Cl:51].[F:1][c:2]1[c:3](-[n:9]2[c:10](=[O:36])[cH:11][cH:12][c:13]3[c:14]2[n:15][c:16]([S:32]([CH3:33])(=[O:34])=[O:35])[n:17][c:18]3-[c:19]2[cH:20][c:21]([C:22](=[O:23])[NH:24][CH2:25][CH2:26][CH3:27])[cH:28][cH:29][c:30]2[CH3:31])[c:4]([F:8])[cH:5][cH:6][cH:7]1.[NH2:37][CH2:38][CH2:39][N:40]([C:41]([O:42][C:43]([CH3:44])([CH3:45])[CH3:46])=[O:47])[CH3:48]>>[F:1][c:2]1[c:3](-[n:9]2[c:10](=[O:36])[cH:11][cH:12][c:13]3[c:14]2[n:15][c:16]([NH:37][CH2:38][CH2:39][N:40]([C:41]([O:42][C:43]([CH3:44])([CH3:45])[CH3:46])=[O:47])[CH3:48])[n:17][c:18]3-[c:19]2[cH:20][c:21]([C:22](=[O:23])[NH:24][CH2:25][CH2:26][CH3:27])[cH:28][cH:29][c:30]2[CH3:31])[c:4]([F:8])[cH:5][cH:6][cH:7]1Participants
4
Reactant 3
Product 1
Sources & evidence
- ORD record
- ord-a373f070c2d145b68166f00594701ebf
- Source dataset
- Training data from https://doi.org/10.1039/C8SC04228D (8/10)
Reaction notes
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