3-Pyridinemethanamine → 2-(3-(4-fluorobenzyl)-2-oxotetrahydropyrimidin-1(2H)-yl)-4-methyl-N-(pyridin-3-ylmethyl)thiazole-5-carboxamide

HRID 307706Notes

Reaction equation

HRID 307706 reaction equation
[Cl:1][c:2]1[cH:3][cH:4][c:5]2[s:6][cH:7][c:8]([CH2:9][N:10]3[CH2:11][CH2:12][N:13]([c:14]4[s:15][c:16]([C:17]([OH:18])=[O:19])[c:20]([CH3:21])[n:22]4)[C:23]3=[O:24])[c:25]2[cH:26]1.[F:27][c:28]1[cH:29][cH:30][c:31]([CH2:32][N:33]2[C:34](=[O:48])[N:35]([c:39]3[s:40][c:41]([C:45](=[O:46])[OH:47])[c:42]([CH3:44])[n:43]3)[CH2:36][CH2:37][CH2:38]2)[cH:49][cH:50]1.[n:51]1[cH:52][c:53]([CH2:57][NH2:58])[cH:54][cH:55][cH:56]1>>[F:27][c:28]1[cH:29][cH:30][c:31]([CH2:32][N:33]2[C:34](=[O:48])[N:35]([c:39]3[s:40][c:41]([C:45](=[O:46])[NH:58][CH2:57][c:53]4[cH:52][n:51][cH:56][cH:55][cH:54]4)[c:42]([CH3:44])[n:43]3)[CH2:36][CH2:37][CH2:38]2)[cH:49][cH:50]1

Participants

4

Reactant 3

HCID 310183-PyridinemethanamineHCID 580315052-(3-((5-Chlorobenzo[b]thiophen-3-yl)methyl)-2-oxoimidazolidin-1-yl)-4-methylthiazole-5-carboxylic acidHCID 580316052-(3-(4-fluorobenzyl)-2-oxotetrahydropyrimidin-1(2H)-yl)-4-methylthiazole-5-carboxylic acid

Product 1

HCID 594812532-(3-(4-fluorobenzyl)-2-oxotetrahydropyrimidin-1(2H)-yl)-4-methyl-N-(pyridin-3-ylmethyl)thiazole-5-carboxamide

Sources & evidence

ORD record
ord-4aab35247e3d4fb9b9ca98bf48ade15b
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (8/10)

Reaction notes

Loading…