HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 30801Generated: October 28, 2026
Thiophosgene → 4-(2-Chloro-5-isothiocyanatophenyl)-3-fluoropyridine
https://huagongshe.com/reaction/30801
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Thiophosgene | HCID 10040 | — |
| Reactant | Sodium Bicarbonate | HCID 516892 | — |
| Reactant | 4-Chloro-3-(3-fluoropyridin-4-yl)benzenamine | HCID 69004657 | — |
| Solvent | Acetone | HCID 180 | — |
| Product | 4-(2-Chloro-5-isothiocyanatophenyl)-3-fluoropyridine | HCID 86045329 | — |
Reaction Steps
The mixture containing 4-chloro-3-(3-fluoropyridin-4-yl)benzenamine (1 eq) and sodium bicarbonate (2 eq) in acetone was treated with thiophosgene (2 eq) and stirred for 5 minutes at 0° C. Reaction then concentrated and partitioned between ethyl acetate and water. Organic layer dried over sodium sulfate and sodium bicarbonate and concentrated to give 4-(2-chloro-5-isothiocyanatophenyl)-3-fluoropyridine. HPLC=5.54 min; MS: MH+=265.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US07423150B2 |
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| Source dataset | uspto-grants-2008_09 |
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| ORD ID | ord-268b0d3cd39b4da6b661c20374790de7 |
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| Source note | uspto-grants-2008_09 |
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