HuagongsheHuagongshe Chemistry Print Report · For research reference only
Water → HCID 69002618, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Water | HCID 962 | — |
| Reactant | Acetyl chloride | HCID 6367 | — |
| Reactant | Diisopropylethylamine | HCID 81531 | — |
| Reactant | 4-(2-Methoxy-4-(methylamino)-5-nitrophenoxy)pyridin-2-amine | HCID 69008180 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | HCID 69002618 | HCID 69002618 | — |
Reaction Steps
Under a nitrogen atmosphere, 4-(2-methoxy-4-(methylamino)-5-nitrophenoxy)-pyridin-2-amine (1 eq) and diisopropylethylamine (4 eq) in methylene chloride was brought to 0° C. Acetyl chloride (1.1 eq) was added dropwise and mixture stirred for 5 minutes. Reaction brought to room temperature and water added. Organic layer washed with brine, dried over sodium sulfate and concentrated to yield N-(4-(2-methoxy-4-(methylamino)-5-nitrophenoxy)pyridin-2-yl)acetamide. HPLC=3.21 min; MS: MH+=333.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07423150B2 |
| Source dataset | uspto-grants-2008_09 |
| ORD ID | ord-8adcb777f22a4460a4df131b3371405f |
| Source note | uspto-grants-2008_09 |