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HRID30814

反应详情

EQUATION

反应方程式

HRID 30814 的结构方程式

REACTANTS

反应物

1
结构：CNc1ccc(Oc2ccnc(NC(=O)CN3CCCC3CO)c2)cc1[N+](=O)[O-]
HCID69003268

未命名化合物

PRODUCTS

生成物

1
结构：CNc1ccc(Oc2ccnc(NC(=O)CN3CCCC3CO)c2)cc1N
HCID69008962

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

2
结构：[Pd]
催化剂HCID23938

Palladium

Pd

结构：CO
溶剂HCID887

Methanol

CH4O

PROCEDURE

实验过程

2-(2-Hydroxymethyl-pyrrolidin-1-yl)-N-[4-(4-methylamino-3-nitro-phenoxy)-pyridin-2-yl]-acetamide was hydrogenated in methanol in the presence of Pd/C for 4 hours. The catalyst was removed via filtration through Celite and filtrate was concentrated to give N-[4-(3-Amino-4-methylamino-phenoxy)-pyridin-2-yl]-2-(2-hydroxymethyl-pyrrolidin-1-yl)-acetamide. MS: MH+=372.4.

WORKUP

后处理

  1. customThe catalyst was removed via filtration through Celite and filtrate
  2. concentrationwas concentrated