HCID 69005928, compound → HCID 69008945, compound

HRID 30828Notes

Reaction equation

HRID 30828 reaction equation
[F:1][C:2]1[CH:7]=[CH:6][C:5]([N+:8]([O-])=O)=[CH:4][C:3]=1[C:11]1([CH3:16])[CH2:15][CH2:14][O:13][CH2:12]1>CO.[Pd]>[F:1][C:2]1[CH:7]=[CH:6][C:5]([NH2:8])=[CH:4][C:3]=1[C:11]1([CH3:16])[CH2:15][CH2:14][O:13][CH2:12]1

Participants

4

Reactant 1

HCID 69005928HCID 69005928, compound

Product 1

HCID 69008945HCID 69008945, compound

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 887MethanolSolvent

Procedure

To 3-(2-fluoro-5-nitrophenyl)-tetrahydro-3-methylfuran in methanol was added a catalytic amount of palladium on carbon (10%). The mixture was allowed to stir for 1 h at room temperature under hydrogen atmosphere. Mixture was filtered though celite and concentrated to afford 4-fluoro-3-(tetrahydro-3-methylfuran-3-yl)benzenamine.

Workup

  1. filtrationMixture was filtered though celite and
  2. concentrationconcentrated

Sources & evidence

ORD record
ord-6401fb0200f543b398f7767300b7b697
Source dataset
uspto-grants-2008_09
Patent number
US07423150B2

Reaction notes

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