2-Thiophen-2-yl-piperazine → (RS)-3-Ethoxycarbonyl-7,9-difluoro-1-methyl-4-oxo-8-[3-(2-thienyl)-1-piperazinyl]-1,4-dihydrobenzo[b][1,8]naphthyridine

HRID 308354Notes

Reaction equation

HRID 308354 reaction equation
[CH2:1]([CH3:2])[O:3][C:4](=[O:5])[c:6]1[c:7](=[O:24])[c:8]2[cH:9][c:10]3[c:11]([n:12][c:13]2[n:14]([CH3:16])[cH:15]1)[c:17]([F:23])[c:18]([F:22])[c:19]([F:21])[cH:20]3.[s:25]1[c:26]([CH:30]2[NH:31][CH2:32][CH2:33][NH:34][CH2:35]2)[cH:27][cH:28][cH:29]1>>[CH2:1]([CH3:2])[O:3][C:4](=[O:5])[c:6]1[c:7](=[O:24])[c:8]2[cH:9][c:10]3[c:11]([n:12][c:13]2[n:14]([CH3:16])[cH:15]1)[c:17]([F:23])[c:18]([N:34]1[CH2:33][CH2:32][NH:31][CH:30]([c:26]2[s:25][cH:29][cH:28][cH:27]2)[CH2:35]1)[c:19]([F:21])[cH:20]3

Participants

3

Reactant 2

HCID 27717262-Thiophen-2-yl-piperazineHCID 194236883-Ethoxycarbonyl-7,8,9-trifluoro-1-methyl-4-oxo-1,4-dihydrobenzo[b][1,8]naphthyridine

Product 1

HCID 54467477(RS)-3-Ethoxycarbonyl-7,9-difluoro-1-methyl-4-oxo-8-[3-(2-thienyl)-1-piperazinyl]-1,4-dihydrobenzo[b][1,8]naphthyridine

Sources & evidence

ORD record
ord-f9c17441db2b42b6b17c671984e05153
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (8/10)

Reaction notes

Loading…