Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Ammonia | HCID 222 | — |
| Reactant | Diethyl [2-[(6-Methoxypurin-9-yl)methoxy]ethyl]phosphonate | HCID 10617397 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | HCID 44361146 | HCID 44361146 | 40% |
Reaction Steps
To a solution of 11 (3.44 g, 10.0 mmol) in MeOH (40 mL) was added a saturated methanolic NH3 solution (100 mL). The solution was heated in a sealed flask at 100° C. for 30 h. The solvent was evaporated and the residue was crystallized from EtOH to give 12 (1.20 g) in 40% yield: mp 190°-193° C.; TLC Rf 0.37 (AcOEt/MeOH=1:1); UV λmax (EtOH): 260 nm (ε14 000); 1H NMR (DMSO-d6 /D2O): δ1.20-1.56 (m, 5 H, CH3 +CH2 P), 3.40-4.10 (m, 2 H, CH2OP), 4.30 (m, 2 H, CH2O), 5.60 (s, 2 H, OCH2N), 7.80, 8.12 (2 s, 2 H, HC(2) +HC(8)). Anal. (C10 H19N6O4P) C, H, N.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US05733890 |
|---|
| Source dataset | uspto-grants-1998_03 |
|---|
| ORD ID | ord-bbab05d627554b729c0070280001d3e6 |
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| Source note | uspto-grants-1998_03 |
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