Thionyl Chloride → methyl 4-(2-chloro-2-oxoethyl)tetrahydro-2H-pyran-4-carboxylate

참여 물질

역할	이름	HCID	투입량
반응물	Thionyl Chloride	HCID 24386	—
반응물	2-[4-(Methoxycarbonyl)oxan-4-yl]acetic acid	HCID 21985695	—
생성물	methyl 4-(2-chloro-2-oxoethyl)tetrahydro-2H-pyran-4-carboxylate	HCID 21985713	99%

반응 단계

Thionyl chloride (20 mL) was added to [4-(methoxycarbonyl)tetrahydro-2H-pyran-4-yl]acetic acid (970 mg, 4.80 mmol) and the solution was stirred at rt for 3 h. The solvent was then removed and mixture was azeotroped with dichloroethane three times to afford methyl 4-(2-chloro-2-oxoethyl)tetrahydro-2H-pyran-4-carboxylate (1.05 g, 99%), which was used without purification in the next step.

출처 및 근거

DOI	10.6084/m9.figshare.5104873.v1
특허 번호	US07423156B2
출처 데이터셋	uspto-grants-2008_09
ORD ID	ord-87b08824e0784ea990f023204302aed6
출처 메모	uspto-grants-2008_09