2-Pyridinecarboxylicacid,5-(2,2,3,3-tetrafluoropropoxy)- → N-[3-(2-amino-4-methyl-4a,5,7,7a-tetrahydrofuro[3,4-e][1,3]oxazin-4-yl)-4-fluorophenyl]-5-(2,2,3,3-tetrafluoropropoxy)pyridine-2-carboxamide

HRID 308507Notes

Reaction equation

HRID 308507 reaction equation
[F:20][C:21]([CH2:22][O:23][c:24]1[cH:25][cH:26][c:27]([C:30](=[O:31])[OH:32])[n:28][cH:29]1)([CH:33]([F:34])[F:35])[F:36].[NH2:1][c:2]1[cH:3][cH:4][c:5]([F:19])[c:6]([C:8]2([CH3:18])[N:9]=[C:10]([NH2:17])[O:11][CH:12]3[CH2:13][O:14][CH2:15][CH:16]23)[cH:7]1>>[NH:1]([c:2]1[cH:3][cH:4][c:5]([F:19])[c:6]([C:8]2([CH3:18])[N:9]=[C:10]([NH2:17])[O:11][CH:12]3[CH2:13][O:14][CH2:15][CH:16]23)[cH:7]1)[C:30]([c:27]1[cH:26][cH:25][c:24]([O:23][CH2:22][C:21]([F:20])([CH:33]([F:34])[F:35])[F:36])[cH:29][n:28]1)=[O:31]

Participants

3

Reactant 2

HCID 574758552-Pyridinecarboxylicacid,5-(2,2,3,3-tetrafluoropropoxy)-HCID 178421628HCID 178421628, compound

Product 1

HCID 72663623N-[3-(2-amino-4-methyl-4a,5,7,7a-tetrahydrofuro[3,4-e][1,3]oxazin-4-yl)-4-fluorophenyl]-5-(2,2,3,3-tetrafluoropropoxy)pyridine-2-carboxamide

Sources & evidence

ORD record
ord-693319b398ca43838acb5f563279f8d1
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (8/10)

Reaction notes

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