1,4-Dioxane → t-Butyl 4-[[5-chloro-4-[(4-chlorophenylthio)-(2,5-difluorophenyl)methyl]pyridin-2-yl]amino]piperidine-1-carboxylate

HRID 309351Notes

Reaction equation

HRID 309351 reaction equation
[CH2:40]1[O:41][CH2:42][CH2:43][O:44][CH2:45]1.[Cl:1][c:2]1[n:3][cH:4][c:5]([Cl:25])[c:6]([CH:8]([c:9]2[c:10]([F:16])[cH:11][cH:12][c:13]([F:15])[cH:14]2)[S:17][c:18]2[cH:19][cH:20][c:21]([Cl:24])[cH:22][cH:23]2)[cH:7]1.[NH2:26][CH:27]1[CH2:28][CH2:29][N:30]([C:33](=[O:34])[O:35][C:36]([CH3:37])([CH3:38])[CH3:39])[CH2:31][CH2:32]1>>[c:2]1([NH:26][CH:27]2[CH2:28][CH2:29][N:30]([C:33](=[O:34])[O:35][C:36]([CH3:37])([CH3:38])[CH3:39])[CH2:31][CH2:32]2)[n:3][cH:4][c:5]([Cl:25])[c:6]([CH:8]([c:9]2[c:10]([F:16])[cH:11][cH:12][c:13]([F:15])[cH:14]2)[S:17][c:18]2[cH:19][cH:20][c:21]([Cl:24])[cH:22][cH:23]2)[cH:7]1

Participants

4

Reactant 3

HCID 312751,4-DioxaneHCID 12682914-Amino-1-Boc-piperidineHCID 231145672,5-Dichloro-4-[(4-chlorophenylthio)-(2,5-difluorophenyl)methyl]pyridine

Product 1

HCID 23114584t-Butyl 4-[[5-chloro-4-[(4-chlorophenylthio)-(2,5-difluorophenyl)methyl]pyridin-2-yl]amino]piperidine-1-carboxylate

Sources & evidence

ORD record
ord-362dcad07c7b473b99b1af0ff552b3c7
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (8/10)

Reaction notes

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