8-amino-2-methyl-3,4-dihydroisoquinolin-1(2H)-one → Diethyl [4-({4-[(2-methyl-1-oxo-1,2,3,4-tetrahydroisoquinolin-8-yl)amino]-5-(trifluoromethyl)pyrimidin-2-yl}amino)benzyl]phosphonate
Reaction equation
[Cl:1][c:2]1[n:3][c:4]([NH:12][c:13]2[cH:14][cH:15][c:16]([CH2:17][P:18]([O:19][CH2:20][CH3:21])([O:22][CH2:23][CH3:24])=[O:25])[cH:26][cH:27]2)[n:5][cH:6][c:7]1[C:8]([F:9])([F:10])[F:11].[NH2:28][c:29]1[cH:30][cH:31][cH:32][c:33]2[c:38]1[C:37](=[O:39])[N:36]([CH3:40])[CH2:35][CH2:34]2>>[c:2]1([NH:28][c:29]2[cH:30][cH:31][cH:32][c:33]3[c:38]2[C:37](=[O:39])[N:36]([CH3:40])[CH2:35][CH2:34]3)[n:3][c:4]([NH:12][c:13]2[cH:14][cH:15][c:16]([CH2:17][P:18]([O:19][CH2:20][CH3:21])([O:22][CH2:23][CH3:24])=[O:25])[cH:26][cH:27]2)[n:5][cH:6][c:7]1[C:8]([F:9])([F:10])[F:11]Participants
3
Reactant 2
Product 1
Sources & evidence
- ORD record
- ord-b112993572654d27b404606f6bcf1135
- Source dataset
- Training data from https://doi.org/10.1039/C8SC04228D (8/10)
Reaction notes
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