4-(Aminomethyl)-1-methyl-1H-indole → 7-chloro-6-[(1-methyl-indol-4-yl-methyl)-amino]-3-(2,2,2-trifluoroacetyl)-2,3,4,5-tetrahydro-1H-benzo[d]azepine

HRID 309469Notes

Reaction equation

HRID 309469 reaction equation
[Cl:1][c:2]1[c:3]([O:19][S:20]([C:21]([F:22])([F:23])[F:24])(=[O:25])=[O:26])[c:4]2[c:5]([cH:17][cH:18]1)[CH2:6][CH2:7][N:8]([C:11]([C:12]([F:13])([F:14])[F:15])=[O:16])[CH2:9][CH2:10]2.[NH2:27][CH2:28][c:29]1[c:30]2[cH:31][cH:32][n:33]([CH3:38])[c:34]2[cH:35][cH:36][cH:37]1>>[Cl:1][c:2]1[c:3]([NH:27][CH2:28][c:29]2[c:30]3[cH:31][cH:32][n:33]([CH3:38])[c:34]3[cH:35][cH:36][cH:37]2)[c:4]2[c:5]([cH:17][cH:18]1)[CH2:6][CH2:7][N:8]([C:11]([C:12]([F:13])([F:14])[F:15])=[O:16])[CH2:9][CH2:10]2

Participants

3

Reactant 2

HCID 185257844-(Aminomethyl)-1-methyl-1H-indoleHCID 574477477-Chloro-3-(2,2,2-trifluoroacetyl)-6-trifluoromethylsulfonyloxy-2,3,4,5-tetrahydro-1H-benzo[d]azepine

Product 1

HCID 866296357-chloro-6-[(1-methyl-indol-4-yl-methyl)-amino]-3-(2,2,2-trifluoroacetyl)-2,3,4,5-tetrahydro-1H-benzo[d]azepine

Sources & evidence

ORD record
ord-8fbf1c5886274d9ca8ef1691c1c246f8
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (8/10)

Reaction notes

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