Chlorosuccinimide → 7-(2'-C-methyl-beta-D-ribofuranosyl)-5-chloro-4-hydroxylamino pyrrolo[2,3-d]pyrimidine

Participants

Reaction Conditions

Reaction Steps

Nucleoside 117 (0.1 mmol) is dissolved in DMF (0.5 mL) and cooled to 0° C. NCS (0.1 mmol) dissolved in DMF (0.5 mL) is then added dropwise and the reaction stirred for 30 minutes at 0° C. and 30 minutes at room temperature. The reaction is quenched with methanol (5 mL) and then concentrated. Column chromatography (SiO2) with MeOH/DCM affords 123.

Provenance & Evidence