Ethanol → 4-[2-Chloro-6-(3-chloro-4-fluoro-phenyl)-pyrimidin-4-yl]-piperazine-1-carboxylic acid tert-butyl ester
Reaction equation
[C:22]([CH3:23])([CH3:24])([CH3:25])[O:26][C:27](=[O:28])[N:29]1[CH2:30][CH2:31][NH:32][CH2:33][CH2:34]1.[CH3:35][CH2:36][OH:37].[Cl:1][c:2]1[n:3][c:4](-[c:9]2[cH:10][c:11]([Cl:16])[c:12]([F:15])[cH:13][cH:14]2)[cH:5][c:6]([Cl:8])[n:7]1.[Na+:21].[O-:17][C:18]([OH:19])=[O:20]>>[Cl:1][c:2]1[n:3][c:4](-[c:9]2[cH:10][c:11]([Cl:16])[c:12]([F:15])[cH:13][cH:14]2)[cH:5][c:6]([N:32]2[CH2:31][CH2:30][N:29]([C:27]([O:26][C:22]([CH3:23])([CH3:24])[CH3:25])=[O:28])[CH2:34][CH2:33]2)[n:7]1Participants
6
Reactant 5
Product 1
Sources & evidence
- ORD record
- ord-49c0e16801364f4bb179424beddffdc2
- Source dataset
- Training data from https://doi.org/10.1039/C8SC04228D (8/10)
Reaction notes
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