HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-methoxy-N-(2,2,3,3,3-pentafluoro-propyl)-malonamic acid → N-[(S)-5-(2-Benzyloxy-ethyl)-6-oxo-6,7-dihydro-5H-dibenzo[b,d]azepin-7-yl]-2-methoxy-N'-(2,2,3,3,3-pentafluoro-propyl)-malonamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-methoxy-N-(2,2,3,3,3-pentafluoro-propyl)-malonamic acid | HCID 21072493 | — |
| Reactant | (S)-7-amino-5-(2-benzyloxy-ethyl)-5H,7H-dibenzo[b,d]azepin-6-one | HCID 58972512 | — |
| Product | N-[(S)-5-(2-Benzyloxy-ethyl)-6-oxo-6,7-dihydro-5H-dibenzo[b,d]azepin-7-yl]-2-methoxy-N'-(2,2,3,3,3-pentafluoro-propyl)-malonamide | HCID 58972466 | — |
Reaction Steps
Using (S)-7-amino-5-(2-benzyloxy-ethyl)-5H,7H-dibenzo[b,d]azepin-6-one and 2-methoxy-N-(2,2,3,3,3-pentafluoro-propyl)-malonamic acid, the title compound was prepared in the same manner as example 1c (99%). White solid. MS: m/e=606(M+H+).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07425551B2 |
| Source dataset | uspto-grants-2008_09 |
| ORD ID | ord-b89da3ec37614a70a7d74746bfde15c2 |
| Source note | uspto-grants-2008_09 |