HuagongsheHuagongshe Chemistry Print Report · For research reference only
(R)-2-fluoro-2-methyl-malonic acid monoethyl ester → (R)-N-[(S)-5-(2-Benzyloxy-ethyl)-6-oxo-6,7-dihydro-5H-dibenzo[b,d]azepin-7-yl]-2-fluoro-2-methyl-malonamic acid ethyl ester
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | (R)-2-fluoro-2-methyl-malonic acid monoethyl ester | HCID 13350488 | — |
| Reactant | (S)-7-amino-5-(2-benzyloxy-ethyl)-5H,7H-dibenzo[b,d]azepin-6-one | HCID 58972512 | — |
| Product | (R)-N-[(S)-5-(2-Benzyloxy-ethyl)-6-oxo-6,7-dihydro-5H-dibenzo[b,d]azepin-7-yl]-2-fluoro-2-methyl-malonamic acid ethyl ester | HCID 58972462 | — |
Reaction Steps
Using (S)-7-amino-5-(2-benzyloxy-ethyl)-5H,7H-dibenzo[b,d]azepin-6-one and (R)-2-fluoro-2-methyl-malonic acid monoethyl ester, the title compound was prepared in the same manner as described for example 1c. Light yellow oil (96%). MS: m/e=505(M+H+).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07425551B2 |
| Source dataset | uspto-grants-2008_09 |
| ORD ID | ord-d080ef81ff0143b4ba953a18dd482243 |
| Source note | uspto-grants-2008_09 |