2,2,3,3,3-Pentafluoropropylamine → HCID 24876787, compound

HRID 31019Notes

Reaction equation

HRID 31019 reaction equation
[CH3:1][O:2][CH2:3][CH2:4][N:5]1[C:11](=[O:12])[C@@H:10]([NH:13][C:14](=[O:19])[CH2:15][C:16]([OH:18])=O)[C:9]2[CH:20]=[CH:21][CH:22]=[CH:23][C:8]=2[C:7]2[CH:24]=[CH:25][CH:26]=[CH:27][C:6]1=2.[F:28][C:29]([F:36])([C:32]([F:35])([F:34])[F:33])[CH2:30][NH2:31]>>[CH3:1][O:2][CH2:3][CH2:4][N:5]1[C:11](=[O:12])[C@@H:10]([NH:13][C:14](=[O:19])[CH2:15][C:16]([NH:31][CH2:30][C:29]([F:36])([F:28])[C:32]([F:35])([F:34])[F:33])=[O:18])[C:9]2[CH:20]=[CH:21][CH:22]=[CH:23][C:8]=2[C:7]2[CH:24]=[CH:25][CH:26]=[CH:27][C:6]1=2

Participants

3

Reactant 2

HCID 790022,2,3,3,3-PentafluoropropylamineHCID 58972491HCID 58972491, compound

Product 1

HCID 24876787HCID 24876787, compound

Procedure

Using N—[(S)-5-(2-methoxy-ethyl)-6-oxo-6,7-dihydro-5H-dibenzo[b,d]azepin-7-yl]-malonamic acid and 2,2,3,3,3-pentafluoropropylamine, the title compound was prepared in the same manner as described for example 1c. White solid (80%). MS: m/e=500(M+H+).

Sources & evidence

ORD record
ord-337c4dfa306946128657750af9fcc618
Source dataset
uspto-grants-2008_09
Patent number
US07425551B2

Reaction notes

Loading…