2,2,3,3,3-Pentafluoropropylamine → (2,2,3,3,3-Pentafluoro-propyl)-carbamic acid (S)-1-[(S)-5-(2-methoxy-ethyl)-6-oxo-6,7-dihydro-5H-dibenzo[b,d]azepin-7-ylcarbamoyl]-ethyl ester

HRID 31021Notes

Reaction equation

HRID 31021 reaction equation
[N+](C1C=CC([O:10][C:11](=O)[O:12][C@H:13]([C:15](=[O:37])[NH:16][C@@H:17]2[C:23](=[O:24])[N:22]([CH2:25][CH2:26][O:27][CH3:28])[C:21]3[CH:29]=[CH:30][CH:31]=[CH:32][C:20]=3[C:19]3[CH:33]=[CH:34][CH:35]=[CH:36][C:18]2=3)[CH3:14])=CC=1)([O-])=O.[F:39][C:40]([F:47])([C:43]([F:46])([F:45])[F:44])[CH2:41][NH2:42]>>[CH3:28][O:27][CH2:26][CH2:25][N:22]1[C:23](=[O:24])[C@@H:17]([NH:16][C:15]([C@@H:13]([O:12][C:11](=[O:10])[NH:42][CH2:41][C:40]([F:47])([F:39])[C:43]([F:46])([F:45])[F:44])[CH3:14])=[O:37])[C:18]2[CH:36]=[CH:35][CH:34]=[CH:33][C:19]=2[C:20]2[CH:32]=[CH:31][CH:30]=[CH:29][C:21]1=2

Participants

3

Reactant 2

HCID 790022,2,3,3,3-PentafluoropropylamineHCID 58972505HCID 58972505, compound

Product 1

HCID 24875484(2,2,3,3,3-Pentafluoro-propyl)-carbamic acid (S)-1-[(S)-5-(2-methoxy-ethyl)-6-oxo-6,7-dihydro-5H-dibenzo[b,d]azepin-7-ylcarbamoyl]-ethyl ester

Procedure

Using carbonic acid (S)-1-[(S)-5-(2-methoxy-ethyl)-6-oxo-6,7-dihydro-5H-dibenzo[b,d]azepin-7-ylcarbamoyl]-ethyl ester 4-nitro-phenyl ester and 2,2,3,3,3-pentafluoropropylamine, the title compound was prepared in the same manner as described for example 5c. White solid (49%). MS: m/e=530(M+H+).

Sources & evidence

ORD record
ord-2d61665e934e4afbb0cafba255805a32
Source dataset
uspto-grants-2008_09
Patent number
US07425551B2

Reaction notes

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