Propanedioic acid, 2-hydroxy-2-methyl-, 1-ethyl ester → HCID 58972530, compound

HRID 31028Notes

Reaction equation

HRID 31028 reaction equation
[NH2:1][C@@H:2]1[C:8](=[O:9])[N:7]([CH2:10][CH2:11][O:12][CH3:13])[C:6]2[CH:14]=[CH:15][CH:16]=[CH:17][C:5]=2[C:4]2[CH:18]=[CH:19][CH:20]=[CH:21][C:3]1=2.[CH2:22]([O:24][C:25](=[O:32])[C:26]([OH:31])([CH3:30])[C:27](O)=[O:28])[CH3:23]>>[CH2:22]([O:24][C:25](=[O:32])[C:26]([OH:31])([CH3:30])[C:27]([NH:1][C@@H:2]1[C:8](=[O:9])[N:7]([CH2:10][CH2:11][O:12][CH3:13])[C:6]2[CH:14]=[CH:15][CH:16]=[CH:17][C:5]=2[C:4]2[CH:18]=[CH:19][CH:20]=[CH:21][C:3]1=2)=[O:28])[CH3:23]

Participants

3

Reactant 2

HCID 13396337Propanedioic acid, 2-hydroxy-2-methyl-, 1-ethyl esterHCID 58972510(S)-7-Amino-5-(2-methoxy-ethyl)-5H,7H-dibenzo[b,d]azepin-6-one

Product 1

HCID 58972530HCID 58972530, compound

Procedure

Using (S)-7-amino-5-(2-methoxy-ethyl)-5H,7H-dibenzo[b,d]azepin-6-one and 2-hydroxy-2-methyl-malonic acid monoethyl ester, the title compound was prepared in the same manner as described for example 1c. Colorless oil. (66%). MS: m/e=426(M+H+).

Sources & evidence

ORD record
ord-402a94f1a8d141a5b7ba9b2c61cd3f8b
Source dataset
uspto-grants-2008_09
Patent number
US07425551B2

Reaction notes

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