2,2,3,3,3-Pentafluoropropylamine → HCID 58972478, compound

HRID 31029Notes

Reaction equation

HRID 31029 reaction equation
[OH:1][C:2]([CH3:29])([C:6]([NH:8][C@@H:9]1[C:15](=[O:16])[N:14]([CH2:17][CH2:18][O:19][CH3:20])[C:13]2[CH:21]=[CH:22][CH:23]=[CH:24][C:12]=2[C:11]2[CH:25]=[CH:26][CH:27]=[CH:28][C:10]1=2)=[O:7])[C:3]([OH:5])=O.[F:30][C:31]([F:38])([C:34]([F:37])([F:36])[F:35])[CH2:32][NH2:33]>>[OH:1][C:2]([CH3:29])([C:3]([NH:33][CH2:32][C:31]([F:38])([F:30])[C:34]([F:37])([F:36])[F:35])=[O:5])[C:6]([NH:8][C@@H:9]1[C:15](=[O:16])[N:14]([CH2:17][CH2:18][O:19][CH3:20])[C:13]2[CH:21]=[CH:22][CH:23]=[CH:24][C:12]=2[C:11]2[CH:25]=[CH:26][CH:27]=[CH:28][C:10]1=2)=[O:7]

Participants

3

Reactant 2

HCID 790022,2,3,3,3-PentafluoropropylamineHCID 58972463HCID 58972463, compound

Product 1

HCID 58972478HCID 58972478, compound

Procedure

Using 2-hydroxy-N—[(S)-5-(2-methoxy-ethyl)-6-oxo-6,7-dihydro-5H-dibenzo[b,d]azepin-7-yl]-2-methyl-malonamic acid and 2,2,3,3,3-pentafluoropropylamine, the title compound was prepared in the same manner as described for example 1c. White solid (78%). MS: m/e=530(M+H+).

Sources & evidence

ORD record
ord-f0bd29f15b2941859bea5f56c516b3c7
Source dataset
uspto-grants-2008_09
Patent number
US07425551B2

Reaction notes

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