HuagongsheHuagongshe Chemistry Print Report · For research reference only
3,3,4,4,4-Pentafluorobutan-1-amine → (R)-N-[(S)-5-(2-Benzyloxy-ethyl)-6-oxo-6,7-dihydro-5H-dibenzo[b,d]azepin-7-yl]-2-fluoro-2-methyl-N'-(3,3,4,4,4-pentafluoro-butyl)-malonamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 3,3,4,4,4-Pentafluorobutan-1-amine | HCID 15754740 | — |
| Reactant | (S)-N-[(S)-5-(2-benzyloxy-ethyl)-6-oxo-6,7-dihydro-5H-dibenzo[b,d]azepin-7-yl]-2-fluoro-2-methyl-malonamic acid | HCID 58972479 | — |
| Product | (R)-N-[(S)-5-(2-Benzyloxy-ethyl)-6-oxo-6,7-dihydro-5H-dibenzo[b,d]azepin-7-yl]-2-fluoro-2-methyl-N'-(3,3,4,4,4-pentafluoro-butyl)-malonamide | HCID 58972516 | — |
Reaction Steps
Using (S)—N—[(S)-5-(2-benzyloxy-ethyl)-6-oxo-6,7-dihydro-5H-dibenzo[b,d]azepin-7-yl]-2-fluoro-2-methyl-malonamic acid and 3,3,4,4,4-pentafluoro-butylamine, the title compound was prepared in the same manner as described for example 1c. White solid (85%). MS: m/e=622(M+H+).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07425551B2 |
| Source dataset | uspto-grants-2008_09 |
| ORD ID | ord-7e90c089aadb41c8a362166e6651c2d9 |
| Source note | uspto-grants-2008_09 |