HCID 21072482, compound → HCID 58972472, compound

HRID 31044Notes

Reaction equation

HRID 31044 reaction equation
[NH2:1][C@@H:2]1[C:8](=[O:9])[N:7]([CH2:10][CH2:11][O:12][CH3:13])[C:6]2[CH:14]=[CH:15][CH:16]=[CH:17][C:5]=2[C:4]2[CH:18]=[CH:19][CH:20]=[CH:21][C:3]1=2.[CH3:22][C:23]([CH3:38])([C:27]([NH:29][CH2:30][C:31]([F:37])([F:36])[C:32]([F:35])([F:34])[F:33])=[O:28])[C:24](O)=[O:25]>>[CH3:13][O:12][CH2:11][CH2:10][N:7]1[C:8](=[O:9])[C@@H:2]([NH:1][C:24](=[O:25])[C:23]([CH3:22])([CH3:38])[C:27]([NH:29][CH2:30][C:31]([F:36])([F:37])[C:32]([F:33])([F:34])[F:35])=[O:28])[C:3]2[CH:21]=[CH:20][CH:19]=[CH:18][C:4]=2[C:5]2[CH:17]=[CH:16][CH:15]=[CH:14][C:6]1=2

Participants

3

Reactant 2

HCID 21072482HCID 21072482, compoundHCID 58972510(S)-7-Amino-5-(2-methoxy-ethyl)-5H,7H-dibenzo[b,d]azepin-6-one

Product 1

HCID 58972472HCID 58972472, compound

Procedure

Using (S)-7-amino-5-(2-methoxy-ethyl)-5H,7H-dibenzo[b,d]azepin-6-one and 2,2-dimethyl-N-(2,2,3,3,3-pentafluoro-propyl)-malonamic acid, the title compound was prepared in the same manner as example 1c (74%). White solid. MS: m/e=528(M+H+).

Sources & evidence

ORD record
ord-460951c7e0874f6791141c969a1dd337
Source dataset
uspto-grants-2008_09
Patent number
US07425551B2

Reaction notes

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