1-(2-Bromoethoxy)-4-fluorobenzene → HCID 58972539, compound

HRID 31046Notes

Reaction equation

HRID 31046 reaction equation
[C:1]([O:5][C:6](=[O:24])[NH:7][C@@H:8]1[C:14](=[O:15])[NH:13][C:12]2[CH:16]=[CH:17][CH:18]=[CH:19][C:11]=2[C:10]2[CH:20]=[CH:21][CH:22]=[CH:23][C:9]1=2)([CH3:4])([CH3:3])[CH3:2].[F:25][C:26]1[CH:35]=[CH:34][C:29]([O:30][CH2:31][CH2:32]Br)=[CH:28][CH:27]=1>>[C:1]([O:5][C:6](=[O:24])[NH:7][C@@H:8]1[C:14](=[O:15])[N:13]([CH2:32][CH2:31][O:30][C:29]2[CH:34]=[CH:35][C:26]([F:25])=[CH:27][CH:28]=2)[C:12]2[CH:16]=[CH:17][CH:18]=[CH:19][C:11]=2[C:10]2[CH:20]=[CH:21][CH:22]=[CH:23][C:9]1=2)([CH3:4])([CH3:2])[CH3:3]

Participants

3

Reactant 2

HCID 20641711-(2-Bromoethoxy)-4-fluorobenzeneHCID 58972520((S)-6-Oxo-6,7-dihydro-5H-dibenzo[b,d]azepin-7-yl)-carbamic acid tert-butyl ester

Product 1

HCID 58972539HCID 58972539, compound

Procedure

Using ((S)-6-oxo-6,7-dihydro-5H-dibenzo[b,d]azepin-7-yl)-carbamic acid tert-butyl ester and 4-fluorophenoxy-ethylbromide, the title product was prepared in the same manner as described for example 1a (84%). White solid. MS: m/e=463(M+H+).

Sources & evidence

ORD record
ord-0af6b94a72a14b4ea3fbb0a97a40efd0
Source dataset
uspto-grants-2008_09
Patent number
US07425551B2

Reaction notes

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