HRID31048

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID21072482

未命名化合物

结构：CC(C)OCCN1C(=O)[C@@H](N)c2ccccc2-c2ccccc21

HCID58972535

未命名化合物

PRODUCTS

生成物

结构：CC(C)OCCN1C(=O)[C@@H](NC(=O)C(C)(C)C(=O)NCC(F)(F)C(F)(F)F)c2ccccc2-c2ccccc21

HCID58972519

未命名化合物

PROCEDURE

实验过程

Using (S)-7-Amino-5-(2-isopropoxy-ethyl)-5H,7H-dibenzo[b,d]azepin-6-one and 2,2-dimethyl-N-(2,2,3,3,3-pentafluoro-propyl)-malonamic acid, the title compound was prepared in the same manner as example 1c (78%). White solid. MS: m/e=556(M+H+).

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-33ffb03b96584c018b1bac880d98608c
来源数据集: uspto-grants-2008_09
DOI: 10.6084/m9.figshare.5104873.v1
专利: US07425551B2
来源说明: uspto-grants-2008_09

反应 SMILES

[NH2:1][C@@H:2]1[C:8](=[O:9])[N:7]([CH2:10][CH2:11][O:12][CH:13]([CH3:15])[CH3:14])[C:6]2[CH:16]=[CH:17][CH:18]=[CH:19][C:5]=2[C:4]2[CH:20]=[CH:21][CH:22]=[CH:23][C:3]1=2.[CH3:24][C:25]([CH3:40])([C:29]([NH:31][CH2:32][C:33]([F:39])([F:38])[C:34]([F:37])([F:36])[F:35])=[O:30])[C:26](O)=[O:27]>>[CH:13]([O:12][CH2:11][CH2:10][N:7]1[C:8](=[O:9])[C@@H:2]([NH:1][C:26](=[O:27])[C:25]([CH3:24])([CH3:40])[C:29]([NH:31][CH2:32][C:33]([F:38])([F:39])[C:34]([F:35])([F:36])[F:37])=[O:30])[C:3]2[CH:23]=[CH:22][CH:21]=[CH:20][C:4]=2[C:5]2[CH:19]=[CH:18][CH:17]=[CH:16][C:6]1=2)([CH3:15])[CH3:14]