HCID 21072482, compound → HCID 58972519, compound

HRID 31048Notes

Reaction equation

HRID 31048 reaction equation
[NH2:1][C@@H:2]1[C:8](=[O:9])[N:7]([CH2:10][CH2:11][O:12][CH:13]([CH3:15])[CH3:14])[C:6]2[CH:16]=[CH:17][CH:18]=[CH:19][C:5]=2[C:4]2[CH:20]=[CH:21][CH:22]=[CH:23][C:3]1=2.[CH3:24][C:25]([CH3:40])([C:29]([NH:31][CH2:32][C:33]([F:39])([F:38])[C:34]([F:37])([F:36])[F:35])=[O:30])[C:26](O)=[O:27]>>[CH:13]([O:12][CH2:11][CH2:10][N:7]1[C:8](=[O:9])[C@@H:2]([NH:1][C:26](=[O:27])[C:25]([CH3:24])([CH3:40])[C:29]([NH:31][CH2:32][C:33]([F:38])([F:39])[C:34]([F:35])([F:36])[F:37])=[O:30])[C:3]2[CH:23]=[CH:22][CH:21]=[CH:20][C:4]=2[C:5]2[CH:19]=[CH:18][CH:17]=[CH:16][C:6]1=2)([CH3:15])[CH3:14]

Participants

3

Reactant 2

HCID 21072482HCID 21072482, compoundHCID 58972535HCID 58972535, compound

Product 1

HCID 58972519HCID 58972519, compound

Procedure

Using (S)-7-Amino-5-(2-isopropoxy-ethyl)-5H,7H-dibenzo[b,d]azepin-6-one and 2,2-dimethyl-N-(2,2,3,3,3-pentafluoro-propyl)-malonamic acid, the title compound was prepared in the same manner as example 1c (78%). White solid. MS: m/e=556(M+H+).

Sources & evidence

ORD record
ord-33ffb03b96584c018b1bac880d98608c
Source dataset
uspto-grants-2008_09
Patent number
US07425551B2

Reaction notes

Loading…