Dimethyl Sulfoxide → 1-(4-((2-hydroxy-2-phenylethyl)(methyl)amino)-2-(4-(oxazol-5-yl)phenylamino)-7,8-dihydropyrido[4,3-d]pyrimidin-6(5H)-yl)ethanone

HRID 310488Notes

Reaction equation

HRID 310488 reaction equation
[CH3:34][NH:35][CH2:36][CH:37]([OH:38])[c:39]1[cH:40][cH:41][cH:42][cH:43][cH:44]1.[CH3:45][S:46]([CH3:47])=[O:48].[F:1][C:2]([F:3])([F:4])[S:5]([O:6][c:7]1[c:8]2[c:9]([n:10][c:11]([NH:13][c:14]3[cH:15][cH:16][c:17](-[c:20]4[cH:21][n:22][cH:23][o:24]4)[cH:18][cH:19]3)[n:12]1)[CH2:25][CH2:26][N:27]([C:29]([CH3:30])=[O:31])[CH2:28]2)(=[O:32])=[O:33]>>[c:7]1([N:35]([CH3:34])[CH2:36][CH:37]([OH:38])[c:39]2[cH:40][cH:41][cH:42][cH:43][cH:44]2)[c:8]2[c:9]([n:10][c:11]([NH:13][c:14]3[cH:15][cH:16][c:17](-[c:20]4[cH:21][n:22][cH:23][o:24]4)[cH:18][cH:19]3)[n:12]1)[CH2:25][CH2:26][N:27]([C:29]([CH3:30])=[O:31])[CH2:28]2

Participants

4

Reactant 3

HCID 679Dimethyl SulfoxideHCID 913N-MethylphenylethanolamineHCID 593337606-Acetyl-2-(4-(oxazol-5-yl)phenylamino)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4-yl trifluoromethanesulfonate

Product 1

HCID 461984811-(4-((2-hydroxy-2-phenylethyl)(methyl)amino)-2-(4-(oxazol-5-yl)phenylamino)-7,8-dihydropyrido[4,3-d]pyrimidin-6(5H)-yl)ethanone

Sources & evidence

ORD record
ord-a167bccaa79d465ebf7257eac3791728
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (8/10)

Reaction notes

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