HRID31052

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID21072482

未命名化合物

结构：N[C@@H]1C(=O)N(CC(O)C(F)(F)F)c2ccccc2-c2ccccc21

HCID58972493

未命名化合物

PRODUCTS

生成物

结构：CC(C)(C(=O)NCC(F)(F)C(F)(F)F)C(=O)N[C@@H]1C(=O)N(CC(O)C(F)(F)F)c2ccccc2-c2ccccc21

HCID24875755

未命名化合物

PROCEDURE

实验过程

Using (S)-7-amino-5-(3,3,3-trifluoro-2-hydroxy-propyl)-5H,7H-dibenzo[b,d]azepin-6-one and 2,2-dimethyl-N-(2,2,3,3,3-pentafluoro-propyl)-malonamic acid, the title compound was prepared in the same manner as example 1c (87%). White solid. MS: m/e=582(M+H+).

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-a73c9099777e46229813de841f7fa4c5
来源数据集: uspto-grants-2008_09
DOI: 10.6084/m9.figshare.5104873.v1
专利: US07425551B2
来源说明: uspto-grants-2008_09

反应 SMILES

[NH2:1][C@@H:2]1[C:8](=[O:9])[N:7]([CH2:10][CH:11]([OH:16])[C:12]([F:15])([F:14])[F:13])[C:6]2[CH:17]=[CH:18][CH:19]=[CH:20][C:5]=2[C:4]2[CH:21]=[CH:22][CH:23]=[CH:24][C:3]1=2.[CH3:25][C:26]([CH3:41])([C:30]([NH:32][CH2:33][C:34]([F:40])([F:39])[C:35]([F:38])([F:37])[F:36])=[O:31])[C:27](O)=[O:28]>>[CH3:25][C:26]([CH3:41])([C:30]([NH:32][CH2:33][C:34]([F:39])([F:40])[C:35]([F:36])([F:38])[F:37])=[O:31])[C:27]([NH:1][C@@H:2]1[C:8](=[O:9])[N:7]([CH2:10][CH:11]([OH:16])[C:12]([F:15])([F:13])[F:14])[C:6]2[CH:17]=[CH:18][CH:19]=[CH:20][C:5]=2[C:4]2[CH:21]=[CH:22][CH:23]=[CH:24][C:3]1=2)=[O:28]