反应详情

温度

100 °C

5,6-Diamino-1-isobutyl-2-thioxo-2,3-dihydro-1H-pyrimidin-4-one (0.22 g, 1.0 mmol) was suspended in formic acid (1.5 mL) and this solution was heated at 100° C. for 1 h. Excess formic acid was evaporated off under reduced pressure. 10% Sodium hydroxide (1.5 mL) was added to the orange solid and the resulting solution was heated at 100° C. for 15 minutes. Water was added and the pH of the solution adjusted to pH 4 with dilute acetic acid. The resulting slurry was stirred for 0.5 h at ambient temperature, then the precipitate was collected by filtration and washed with water. Yield: (0.21 g, 90%).

1. customExcess formic acid was evaporated off under reduced pressure
2. addition10% Sodium hydroxide (1.5 mL) was added to the orange solid
3. temperaturethe resulting solution was heated at 100° C. for 15 minutes
4. additionWater was added
5. filtrationthe precipitate was collected by filtration
6. washwashed with water