反应详情

温度

130 °C

A mixture of 5,6-diamino-1-isobutyl-2-thioxo-2,3-dihydro-1H-pyrimidin-4-one (Example 6 (c), 0.70 g, 3.26 mmol) and triethylorthoacetate (10 mL) was heated at 130° C. for 2 h and 40 minutes. Then the reaction mixture was cooled on an ice-bath, the solid filtered off and washed with ethanol (4×2 mL). The solid was dried in vacuo yielding the title compound (0.71 g, 95%).

1. temperatureThen the reaction mixture was cooled on an ice-bath
2. filtrationthe solid filtered off
3. washwashed with ethanol (4×2 mL)
4. customThe solid was dried in vacuo