反应详情

Sodium methoxide (0.81 g, 21.2 mmol, 1.05 eq.) was added to a solution of 3-methoxypropylthiourea (3.00 g, 20.2 mmol) in ethanol (10 mL). Ethyl cyanoacetate (2.18 mL, 20.2 mmol) in ethanol (10 mL) was added and the resulting white slurry was heated to reflux for 2.5 h. The solvent was evaporated and the remaining pale brown oil was treated with 2M acetic acid (15 mL,). The white crystals were filtered off and washed with acetic acid to give the title compound (2.10 g, 48%).

1. temperaturethe resulting white slurry was heated
2. temperatureto reflux for 2.5 h
3. customThe solvent was evaporated
4. additionthe remaining pale brown oil was treated with 2M acetic acid (15 mL,)
5. filtrationThe white crystals were filtered off
6. washwashed with acetic acid