Sodium Nitrite → HCID 86601058, compound

HRID 31067Notes

Reaction equation

HRID 31067 reaction equation
[NH2:1][C:2]1[N:7]([CH2:8][CH:9]2[CH2:13][CH2:12][CH2:11][O:10]2)[C:6](=[S:14])[NH:5][C:4](=[O:15])[CH:3]=1.[N:16]([O-])=[O:17].[Na+]>C(O)(=O)C>[NH2:1][C:2]1[N:7]([CH2:8][CH:9]2[CH2:13][CH2:12][CH2:11][O:10]2)[C:6](=[S:14])[NH:5][C:4](=[O:15])[C:3]=1[N:16]=[O:17]

Participants

4

Reactant 2

HCID 23668193Sodium NitriteHCID 252523746-Amino-2,3-dihydro-1-[(tetrahydro-2-furanyl)methyl]-2-thioxo-4(1H)-pyrimidinone

Product 1

HCID 86601058HCID 86601058, compoundYield 90.6%

Reagents, catalysts & solvents 1

HCID 176Acetic AcidSolvent

Conditions

Temperature
75 °C

Procedure

6-Amino-1-(2-tetrahydrofuryl-methyl)-2-thioxo-2,3-dihydro-1H-pyrimidin-4-one (1.3 g, 5.6 mmol) was suspended in 10% aqueous acetic acid (25 mL). Sodium nitrite (0.43 g, 6.2 mmol) was added and this mixture was heated at 75° C. for 1 h. The purple solid was collected by filtration, washed and dried, giving the title product (1.3 g, 90%).

Workup

  1. filtrationThe purple solid was collected by filtration
  2. washwashed
  3. customdried

Sources & evidence

ORD record
ord-8ffd637817af4bb4bd7285c50fd0b37e
Source dataset
uspto-grants-2008_09
Patent number
US07425560B2

Reaction notes

Loading…