5-Ethynylpyrimidin-2-amine → 5-[5-(4-Chloro-phenyl)-7-cyclopropyl-pyrazolo[1,5-a]pyrimidin-3-ylethynyl]-pyrimidin-2-ylamine

HRID 310676Notes

Reaction equation

HRID 310676 reaction equation
[C:21](#[CH:22])[c:23]1[cH:24][n:25][c:26]([NH2:29])[n:27][cH:28]1.[Cl:1][c:2]1[cH:3][cH:4][c:5](-[c:8]2[n:9][c:10]3[n:11]([c:12]([CH:14]4[CH2:15][CH2:16]4)[cH:13]2)[n:17][cH:18][c:19]3[I:20])[cH:6][cH:7]1>>[Cl:1][c:2]1[cH:3][cH:4][c:5](-[c:8]2[n:9][c:10]3[n:11]([c:12]([CH:14]4[CH2:15][CH2:16]4)[cH:13]2)[n:17][cH:18][c:19]3[C:22]#[C:21][c:23]2[cH:24][n:25][c:26]([NH2:29])[n:27][cH:28]2)[cH:6][cH:7]1

Participants

3

Reactant 2

HCID 161090215-Ethynylpyrimidin-2-amineHCID 670008755-(4-Chloro-phenyl)-7-cyclopropyl-3-iodo-pyrazolo[1,5-a]pyrimidine

Product 1

HCID 670011815-[5-(4-Chloro-phenyl)-7-cyclopropyl-pyrazolo[1,5-a]pyrimidin-3-ylethynyl]-pyrimidin-2-ylamine

Sources & evidence

ORD record
ord-f25924d55feb47778eb24aea0619f8b4
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (8/10)

Reaction notes

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