Formic Acid → HCID 86601062, compound

HRID 31071Notes

Reaction equation

HRID 31071 reaction equation
[NH2:1][C:2]1[C:3](=[O:16])[NH:4][C:5](=[S:15])[N:6]([CH2:9][C:10]2[O:11][CH:12]=[CH:13][CH:14]=2)[C:7]=1[NH2:8].[CH:17](O)=O>>[O:11]1[CH:12]=[CH:13][CH:14]=[C:10]1[CH2:9][N:6]1[C:7]2[N:8]=[CH:17][NH:1][C:2]=2[C:3](=[O:16])[NH:4][C:5]1=[S:15]

Participants

3

Reactant 2

HCID 284Formic AcidHCID 86601063HCID 86601063, compound

Product 1

HCID 86601062HCID 86601062, compound

Conditions

Temperature
70 °C

Procedure

5,6-Diamino-1-(2-furyl-methyl)-2-thioxo-2,3-dihydro-1H-pyrimidin-4-one (0.12 g, 0.51 mmol) in formic acid (0.5 mL) was stirred at ambient temperature for 0.5 h. The excess of formic acid was evaporated off and the resulting solid dissolved in 10% sodium hydroxide solution (3 mL). This solution was heated at 70° C. for 0.5 h. The reaction mixture was neutralized with 2M hydrochloric acid. The resulting precipitate was collected by filtration, washed with water, and dried. Yield: (0.047 g, 37%).

Workup

  1. customThe excess of formic acid was evaporated off
  2. dissolutionthe resulting solid dissolved in 10% sodium hydroxide solution (3 mL)
  3. filtrationThe resulting precipitate was collected by filtration
  4. washwashed with water
  5. customdried

Sources & evidence

ORD record
ord-60509d0eea7742de83c9d9f3c8f38912
Source dataset
uspto-grants-2008_09
Patent number
US07425560B2

Reaction notes

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