Potassium Cation → N-[6-[6-chloro-5-(methanesulfonamido)-3-pyridinyl]-1-methylindazol-4-yl]-2-[(2,6-dimethylmorpholin-4-yl)methyl]-1,3-thiazole-4-carboxamide

HRID 310877Notes

Reaction equation

HRID 310877 reaction equation
[Br:38][c:39]1[cH:40][c:41]([NH:46][S:47](=[O:48])(=[O:49])[CH3:50])[c:42]([Cl:45])[n:43][cH:44]1.[CH2:59]1[O:60][CH2:61][CH2:62][O:63][CH2:64]1.[CH3:1][CH:2]1[O:3][CH:4]([CH3:37])[CH2:5][N:6]([CH2:8][c:9]2[s:10][cH:11][c:12]([C:14](=[O:15])[NH:16][c:17]3[c:18]4[cH:19][n:20][n:21]([CH3:36])[c:22]4[cH:23][c:24]([B:26]4[O:27][C:28]([CH3:29])([CH3:30])[CH2:31][C:32]([CH3:33])([CH3:34])[O:35]4)[cH:25]3)[n:13]2)[CH2:7]1.[K+:56].[K+:57].[K+:58].[OH2:65].[P:51]([O-:52])([O-:53])([O-:54])=[O:55]>>[CH3:1][CH:2]1[O:3][CH:4]([CH3:37])[CH2:5][N:6]([CH2:8][c:9]2[s:10][cH:11][c:12]([C:14](=[O:15])[NH:16][c:17]3[c:18]4[cH:19][n:20][n:21]([CH3:36])[c:22]4[cH:23][c:24](-[c:39]4[cH:40][c:41]([NH:46][S:47](=[O:48])(=[O:49])[CH3:50])[c:42]([Cl:45])[n:43][cH:44]4)[cH:25]3)[n:13]2)[CH2:7]1

Participants

7

Reactant 6

HCID 813Potassium Cation3×HCID 962WaterHCID 1061PhosphateHCID 312751,4-DioxaneHCID 59519513N-(5-bromo-2-chloro-3-pyridinyl)methanesulfonamideHCID 178430442HCID 178430442, compound

Product 1

HCID 75045232N-[6-[6-chloro-5-(methanesulfonamido)-3-pyridinyl]-1-methylindazol-4-yl]-2-[(2,6-dimethylmorpholin-4-yl)methyl]-1,3-thiazole-4-carboxamide

Sources & evidence

ORD record
ord-78c6822a8ed442818cabf9802822d854
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (8/10)

Reaction notes

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