Acetone → 1,2-Dihydro-4-[4-(dimethylaminomethyl)phenyl]-5-hydroxy-1-oxoisoquinoline methanesulfonate

Participants

Reaction Steps

To a suspension of the compound of Example 1 (414 mg, 1.41 mmol) in methanol (15 mL) was added methanesulfonic acid (101 μL, 1.55 mmol), and the mixture was stirred for 30 minutes at room temperature. Acetone was added to the residue obtained by concentrating the reaction mixture under reduced pressure. The precipitated crystals were collected by filtration, washed with acetone, and then dried, thereby affording 492 mg of the title compound as light brown powder. Yield 88%.

Provenance & Evidence