HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrogen Bromide → 1,2-Dihydro-4-[4-(dimethylaminomethyl)phenyl]-5-hydroxy-1-oxoisoquinoline hydrobromide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrogen Bromide | HCID 260 | — |
| Reactant | 4-(4-((dimethylamino)methyl)phenyl)-5-hydroxyisoquinolin-1(2H)-one | HCID 9839073 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | 1,2-Dihydro-4-[4-(dimethylaminomethyl)phenyl]-5-hydroxy-1-oxoisoquinoline hydrobromide | HCID 23077425 | 98.1% |
Reaction Steps
To a suspension of the compound of Example 1 (200 mg, 679 μmol) in methanol (10 mL) was used 1 mol/L hydrobromic acid (679 μL, 679 μmol), and, through the process similar to Example 121, 250 mg of the title compound were afforded as light brown powder. Yield 97%.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07425563B2 |
| Source dataset | uspto-grants-2008_09 |
| ORD ID | ord-9eafabbab21d454e8b249be1e2a03e96 |
| Source note | uspto-grants-2008_09 |