Methanol → 1-(4-(4-(4-(4-Aminopiperidin-1-yl)-5-fluoropyrimidin-2-ylamino)phenyl)piperazin-1-yl)ethanone

HRID 311314Notes

Reaction equation

HRID 311314 reaction equation
[C:1]([CH3:2])(=[O:3])[N:4]1[CH2:5][CH2:6][N:7]([c:10]2[cH:11][cH:12][c:13]([NH:16][c:17]3[n:18][cH:19][c:20]([F:40])[c:21]([N:23]4[CH2:24][CH2:25][CH:26]([NH:29][C:30](=[O:31])[O:32][CH2:33][c:34]5[cH:35][cH:36][cH:37][cH:38][cH:39]5)[CH2:27][CH2:28]4)[n:22]3)[cH:14][cH:15]2)[CH2:8][CH2:9]1.[CH3:43][OH:44].[H:41][H:42]>>[C:1]([CH3:2])(=[O:3])[N:4]1[CH2:5][CH2:6][N:7]([c:10]2[cH:11][cH:12][c:13]([NH:16][c:17]3[n:18][cH:19][c:20]([F:40])[c:21]([N:23]4[CH2:24][CH2:25][CH:26]([NH2:29])[CH2:27][CH2:28]4)[n:22]3)[cH:14][cH:15]2)[CH2:8][CH2:9]1

Participants

4

Reactant 3

HCID 887MethanolHCID 44467167Benzyl 1-(2-(4-(4-acetylpiperazin-1-yl)phenylamino)-5-fluoropyrimidin-4-yl)piperidin-4-ylcarbamateHCID 178418361HCID 178418361, compound

Product 1

HCID 444671681-(4-(4-(4-(4-Aminopiperidin-1-yl)-5-fluoropyrimidin-2-ylamino)phenyl)piperazin-1-yl)ethanone

Sources & evidence

ORD record
ord-c2419441cc864014b6b346a4d743ed0b
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (8/10)

Reaction notes

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